The liver was the first metastatic site in most 929% cases The median disease-free interval was 26 months interquartile range 34 Median overall survival after detection of the first metastasis was 8 months interquartile range 14 The baseline characteristics of the primary uveal melanoma were not associated with survival in patients with stage IV disease, In the multivariate analysis, the following …
Assessing Outcomes for Patients with Uveal Melanoma
A: Uveal melanoma UM sometimes called ocular melanoma is a rare type of cancer and there are no definitive guidelines for its treatment once it spreads to other organs Because of the location of the tumor and interference with vision most patients are diagnosed when there are no metastases However, many patients up to 50% who have successful surgery and/or radiation for the primary …
Immunoembolization of malignant liver tumors including
In uveal melanoma the most common site of metastatic disease is the liver, and a number of hepatic-directed therapies are available including surgery, radiofrequency ablation, and embolization, Conventional systemic chemotherapy has shown poor response rates in uveal melanoma,
Clinical predictors of survival in metastatic uveal melanoma
Metastatic Uveal Melanoma
Immunological aspect of the liver and metastatic uveal melanoma Introduction Uveal melanoma UM originates from the uveal tract of the eye iris ciliary body and choroid The Immunological microenvironment of primary uveal melanoma The eye is considered an immune-privileged organ It has
Uveal Melanoma Metastatic to the Liver: The Role of
metastatic uveal melanoma in liver
A total of 63 treatment-naïve patients presented with uveal melanoma metastases occupying 50% or more of the normal liver parenchyma between January 2004 and November 2011 Patients with intrahepatic tumor burden 50% or more no extensive extrahepatic metastases limiting life expectancy to less than 3 months Eastern Cooperative Oncology Group ECOG 0–2 performance status, and …
Liver function tests in metastatic uveal melanoma
Researchers performed a retrospective study of 73 patients with uveal melanoma metastatic to the liver seen at Cleveland Clinic between 2004 and 2016 median age 63 years More than half of patients 58% had uveal melanoma located in the choroid Episcleral plaque brachytherapy was the most common treatment 52% with enucleation at 47% and one patient receiving proton …
The bidirectional crosstalk between metastatic uveal
Setting: The Israel uveal melanoma center at the Hadassah University Hospital Patient population: A total of 307 uveal melanoma patients who were diagnosed with uveal melanoma and followed between the years 1988 and 1998 Of them 30 metastatic patients who had regular follow-up by liver function tests LFTs and liver imaging were included in this study, Eighty nonmetastatic patients were …
Uveal Melanoma Metastatic in the Liver Concept Id: C4725629
Unlike cutaneous melanoma that has a widespread metastatic pattern uveal melanoma has a significant predilection for metastasis to the liver Approximately 50% of the patients will develop metastatic liver disease Although there are effective local therapies to eliminate and prevent recurrence within the eye radioactive plaque proton beam enucleation there are no effective systemic …
Combined treatment of uveal melanoma liver metastases
Uveal Melanoma Metastatic in the Liver Concept Id: C4725629 A melanoma that originates from melanocytes of the uveal tract and has spread to the liver Uveal Melanoma Metastatic in the Liver, MedGen UID:
Immunological aspect of the liver and metastatic uveal
Uveal melanoma is the most common primary ocular neoplasm in adults It is peculiar for its hematogenous dissemination and its high propensity to spread to the liver Current treatments rarely prolong patient survival We hypothesized that metastatic uveal melanoma cells modulate the …
How to Treat Uveal Melanoma that Recurs in the Liver
Uveal Melanoma Metastatic to the Liver: Chemoembolization
Thirty-one assessable patients with uveal melanoma demonstrated two complete responses eight partial responses and 10 occurrences of stable disease in their hepatic metastases The median overall survival of intent-to-treat patients who had metastatic uveal melanoma was 14,4 months Multivariate analyses indicated that female sex high doses of GM-CSF > or = 1,500 microg, and regression of hepatic …
Most frequently about 60-80% of cases uveal melanoma metastasizes into the liver due to the biologicalanatomical peculiarities hematogenous dissemination subsequent homing of cancer cells or their preferential survival in the liver and other factors [2–4] other common sites of metastasis are lungs and bones ,
Metastatic disease from uveal melanoma: treatment options
Uveal melanoma represents ∼85% of all ocular melanomas and up to 50% of patients develop metastatic disease Metastases are most frequently localised to the liver and as few patients are candidates for potentially curative surgery this is associated with a poor prognosis, There is currently little published evidence for the optimal management and treatment of metastatic uveal melanoma and the lack of …