irinotecan camptothecin synthesis Prior art date 2013-12-03 Application number HUE14802435A Other languages English en Hungarian hu Inventor Alexander Zabudkin Viktor Matvienko Original Assignee Synbias Pharma Ag Priority date The priority date is an assumption and is not a legal conclusion, Google has not performed a legal analysis and makes no representation as to the accuracy of the
HUE032281T2
US9765083B2
i During the S phase of the DNA synthesis Irinotecan binds with the topoisomerase I-DNA complex This prevents the relegation of the DNA strands, , ii, The ternary complex so formed interferes with the moving replication fork, iii, The lethal double-stranded breaks in the mammalian cells cannot be repaired by the cells and thus apoptosis takes place, [2]
Synthesis metabolite analysis and in vivo evaluation of
EP2881396A1
CA2924256C
The present invention relates to a method for the synthesis of 7-ethyl-10-[4-1-piperidino-1-piperidino]carbonyloxy-camptothecin i,e, iriniotecan, comprising: a preparing
IRINOTECAN Synthesis SAR MCQStructure,Chemical
irinotecan synthesis reaction Prior art date 2013-12-03 Legal status The legal status is an assumption and is not a legal conclusion, Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed, Active Application number US15/023,827 Other languages English en Other versions US20160264590A1 en Inventor Alexander Zabudkin Viktor Matvienko
Synthesis mechanisms of action and toxicity of novel
Methods: [11C]Irinotecan was synthesized by two routes using [11C]phosgene and [11C]carbon dioxide fixation Metabolites in the plasma of mice following injection of [11C] irinotecan were investigated using a combination of column-switching high-performance liquid chromatography HPLC and on-line solid-phase extraction SPE, Whole-body PET studies were conducted in wild-type mice …
irinotecan camptothecin synthesis Prior art date 2013-12-03 Application number HUE14802435A Other languages Hungarian hu Inventor Alexander Zabudkin Viktor Matvienko Original Assignee Synbias Pharma Ag Priority date The priority date is an assumption and is not a legal conclusion, Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed
irinotecan synthesis camptothecin Prior art date 2013-12-03 Legal status The legal status is an assumption and is not a legal conclusion, Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed, Active Application number CA2924256A Other languages English en French fr Other versions CA2924256A1 en Inventor Alexander Zabudkin …
WO2012032531A1
irinotecan synthesis Prior art date 2013-12-03 Application number IL244487A Other languages English en Hebrew he Other versions IL244487A en Original Assignee Synbias Pharma Ag Priority date The priority date is an assumption and is not a legal conclusion, Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed, 2013-12-03 Filing date
HUE032281T2
Synthesis mechanisms of action and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents Twenty novel aminophosphonates derivatives 5a-5j and 6a-6j conjugated irinotecan were synthesized through esterification reaction and evaluated their anticancer activities using MTT assay,
The application and synthesis method of irinotecan
IL244487D0
Inhibiteurs des checkpoints immunologiques Les premiers signaux d’efficacité des inhibiteurs de checkpoints immunologiques ICI ciblant PD-1 et PD-L1 dans le carcinome urothélial remontent à 2014 avec les résultats des phases I du pembrolizumab anti-PD-1 et de l’atezolizumab anti-PD-L1 [5] [6]
Disclosed herein is a highly safe and easily scalable process for the production of 7-Ethyl- 10-hydroxycamptothecin and its conversion to Irinotecan hydrochloride by total synthesis, Process for
Innovations dans les traitements systémiques du carcinome
From pharmaceutical raw materials suppliers we know that irinotecan is a semi-synthetic derivative of camptothecin Camptothecin can specifically binding with topoisomerase I the latter can induce reversible single strand breaks, so that make the DNA double helix unwinding; irinotecan and its active metabolite of SN-38 can combine with topoisomerase I-DNA complexes, thereby preventing …
irinotecan synthesis
Irinotecan
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer, Irinotecan is a semisynthetic derivative of camptothecin, Camptothecins interact specifically with topoisomerase I, an enzyme in the cell nucleus that regulates DNA topology and facilitates nuclear processes such as DNA replication, recombination, and repair, During these processes, …